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A phase III, randomized, double-blind, parallel-group study showed that the combination of SGLT2 inhibitors and DPP-4 inhibitors resulted in the reductions of HbA1c (mean baseline 7.908.02% [62.864.1 mmol/mol]), FPG, serum uric acid, SBP, and hypoglycemic risk were superior to those with the individual components in patients with T2DM

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Potent 2D6 inhibitors include fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft) at dosages 150 mg, but many other antidepressants can inhibit it (see table on page 8)

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