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Extrinsic aging is predominantly influenced by sun exposure (photoaging), although smoking and pollution also play a role.1 Intrinsic and extrinsic aging overlap in clinical practice.1 Demand for strategies to mitigate the signs of skin aging is high.2 Recent studies suggest that regular exercise, apart from improving quality of life and reducing the risk of mortality and chronic disease,2 might also reduce the thickness of the stratum corneum and improve dermal thickness and collagen content.3 Diet is also important, with a number of studies highlighting its role in the prevention of aging

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Retatrutide may become the first effective pharmaceutical treatment for this condition

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Andrew: This podcast has always been about bringing in diverse outlooks on the same things

They include nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), activator protein 1 (AP-1), p53, and nuclear factor erythroid 2-related factor 2 (NRF2) (219, 220)