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It requires two copper ions at its active site to catalyse the conversion of tyrosine to DOPA and then to DOPAquinone the precursor of eumelanin

The non-disease-specific mortality was then adjusted using hazard ratios (HRs) per unit change in BMI, sourced from a study conducted on a large cohort of adults from the UK Clinical Practice Research Datalink (CPRD) database ( N = 3.6 million) [35], to account for the increased mortality associated with overweight and obesity

10.3389/fcvm.2022.1010693 114 MazidiM.RezaieP.GaoH

Fueling the System: The Critical Micronutrients Understanding the mechanism reveals a crucial fact: physiological detoxification must be built, not bought

Following data normalization and quality control, four samples were excluded from further analyses (Supplemental Figure S1)

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