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Neuroinflammation and immune activation Chronic inflammation is a unifying feature in many NDDs, and gut microbes are emerging as key modulators of systemic and CNS inflammatory tone

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Indirect 5-Alpha Reductase Inhibition We can decrease DHT by inhibiting 5-alpha reductase through two major pathways: direct versus indirect 5-AR inhibition

Key areas of future research will include the signaling pathways and molecular mechanisms involved, endothelial repair, and interactions between endothelial cells and other cell types in sepsis (110)

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