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demonstrated that the co-administration of Diane-35 and metformin resulted in decreased androgen receptor expression, increased GLUT4 expression, and modulation of cellular autophagy initiation by inhibiting IGF-1, ultimately leading to the suppression of EC development mediated by the mTORC pathway (Liu Y

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The oxidized form of guanine, 8-oxo-2-deoxyguanosine (8-oxo-dG), is a valuable marker of oxidative DNA damage during carcinogenesis (116, 117)