Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects
Living skin has blood circulation that clears delivered molecules at a rate the Franz cell does not capture, and a longer functional half-life of the peptide in tissue is implied but not directly measured
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Methods/design The proposed study involves a controlled, randomised, multicentre, parallel, non-inferiority clinical trial lasting one year, involving 23 primary healthcare centres in the Madrid region (Spain), and patients 65 years of age