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Patients with Renal Impairment In adult patients with type 2 diabetes mellitus with mild (eGFR: 60 to less than 90 mL/min/1.73 m2), moderate (eGFR: 30 to less than 60 mL/min/1.73 m2), and severe (eGFR: less than 30 mL/min/1.73 m2) renal impairment and patients on dialysis due to kidney failure, AUC of empagliflozin increased by approximately 18%, 20%, 66%, and 48%, respectively, compared to subjects with normal renal function

In recent years, the employment of Mendelian randomization (MR) has facilitated the ability to deduce causal connections between modifiable environmental exposures and outcomes, thus garnering growing attention [20]

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[2] [3] Taking berberine with food may reduce gastrointestinal side effects

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13 , e034131 (2024)