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Women of childbearing potential must comply with the MHRA Pregnancy Prevention Programme for topiramate, using highly effective contraception and signing risk acknowledgement forms

Triple agonist targeting GLP-1, GIP, and glucagon receptors

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Back Lasker Foundation (2024) 'GLP-1-based therapy for obesity'

A gradual step-down gives the researcher time to implement dietary and behavioral strategies at each lower dose level, building habits that can partially compensate for the loss of pharmacological support