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Repeated freeze-thaw cycles cause ice crystal formation that shears peptide bonds and precipitates the copper complex
The body is tired but the mind is very alert
Failure of DNA repair induces apoptosis through p53 activation, mitochondrial pathway induction, and persistent DNA damage response (DDR) signaling 8-10
24,168,170,181,190 Conversely, smoking cessation reduces the risk of developing CKD and is of benefit to patients where the condition pre-exists
Severe symptoms may not be reversible, which is why prevention and early treatment are important
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