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Participants with OCD showed significantly higher levels of Glu (independent sample t -test(58) = 2.08, p = 0.02, p -FDR = 0.04, Cohens d = 0.53 , 95% CI[0.016, 0.83]), Glu:GABA ratio (MannWhitney U = 618, p = 0.006, p -FDR = 0.02, p 2 = 0.10, 95% CI[0.05, 0.70]), and Glx (independent sample t -test(58) = 2.13, p = 0.02, p -FDR = 0.05, Cohens d = 0.55 , 95% CI[0.03, 1.13]) within the ACC voxel

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However, practical considerations exist