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1998) analyzed CYP2A5 expression in C3H, C57BL/6, and B6C3F1 mice and found expression in phenobarbital promoted preneoplastic and neoplastic liver lesions in all three strains

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The article names significant kidney or liver disease, diabetic retinopathy, and active gallbladder disease as needing careful evaluation before starting, on top of the contraindications it lists: personal or family history of medullary thyroid cancer and multiple endocrine neoplasia syndrome type 2

If incomplete, the submission should be pended because follow-up and coordination may be delayed

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