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The HC calculation was done using this formula: where S1 represents the total protein content of sample (before heating), and S2 represents the protein content of supernatant (after heating)
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While specific therapies for IBM are still lacking, NAD + boosters have shown promising results in various models, including nematodes with amyloid aggregation, aged rodents, and human muscle cells from IBM patients
The Phase 2 trial showed 24.2% weight loss at 48 weeks, and Phase 3 data suggests 28.7% at 68 weeks
After the cells were treated, the original medium was discarded, and the cells were rinsed three times with PBS