An ROS-responsive artesunate prodrug nanosystem co-delivers dexamethasone for rheumatoid arthritis treatment through the HIF-1/NF-B cascade regulation of ROS scavenging and macrophage repolarization
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These findings lay the foundation for understanding dietary lipid-induced intestinal inflammation
Methods: A375 melanoma cells were treated with HC in vitro to evaluate its impact on cell proliferation, migration, and morphology
NO-releasing agents, such as JS-K ( O 2 -(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate) 123 and PABA/NO ( O 2 -[2,4-dinitro-5-( N -methyl- N -4 carboxyphenylamino)phenyl] 1- N , N -dimethylamino)diazen-1-ium-1,2-diolate) 124 , are able to induce differentiation and cell death in a variety of cancer cells through GSH consumption, DNA synthesis inhibition and inhibition of enzymes involved in the defense against cell damage
Metabolic reprogramming of tumor-associated macrophages using glutamine antagonist jhu083 drives tumor immunity in myeloid-rich prostate and bladder cancers