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Additionally, the expression of common CSC markers, such as CD133 and CD44, is not exclusive to tumorigenic cells and may also be found in normal tissue stem cells or even non-tumorigenic cancer cells

The phase 2 GeparOLA study compared paclitaxel + olaparib and paclitaxel + carboplatin in neoadjuvant settings in patients with HER2, HRD+ early breast cancer

Using IV therapy to administer high doses of Vitamin C has been shown to reduce this toxicity, decreasing infections, bone marrow toxicity, liver and pancreatic toxicity, gastrointestinal toxicity, and dermatological toxicity

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doi: 10.3322/caac.21820 4 SiegelRLKratzerTBGiaquintoANSungHJemalA