Freeman JM, Vining EPG, Cost S, Singhi P
Someone with specific GIPR or GLP1R variants might respond better to Tirzepatide (which activates both GLP-1 and GIP receptors) than to Semaglutide alone, offering superior hunger suppression and potentially easier weight maintenance
Aging Cell 12 , 333344 (2013)
Nakahara, M
doi: 10.1507/endocrj.47.supplmarch_s53 25 HosodaH.KojimaM.MatsuoH.KangawaK
Abbreviations SGLT-2i: Sodium-dependent glucose transporters 2 inhibitors GLP-1 Ras: Glucagon-like peptide 1 COVTs: Cardiovascular outcomes trials MACE: Major adverse cardiovascular events HHF: Hospitalization for heart failure CV death: Cardiovascular death HHF or CV death: Hospitalization for heart failure or cardiovascular death MI: Myocardial infarction T2DM: Type 2 diabetes mellitus RoB 2: Risk-of-bias tool CIs: Confidence intervals HRs: Hazard ratios References Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, Stein C, Basit A, Chan JCN, Mbanya JC, et al