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These compounds work by mimicking hormones that regulate appetite and glucose metabolism, producing significant weight loss primarily through reduced food intake

The tolerability of GLP-1 drugs can also pose a challenge, as gastrointestinal issues like nausea, vomiting, diarrhea and constipation can occur from taking them

Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans

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Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association