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This mechanistic complementarity leads to a more efficient wound healing cascade, facilitating rapid closure and organized tissue reconstruction under experimental conditions

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Studies of animal models have shown that such heterozygotes have a higher incidence of cardiomyopathy with aging and may be at risk for cardiac abnormalities when additional cardiac burdens are imposed.37), 38) A genetic epidemiological study in Japan showed that the prevalence of heterozygotes for SLC22A5 mutations was 1.01%, and the echocardiography analysis revealed that they were predisposed to late onset benign cardiac hypertrophy (odds ratio 15.1, 95% CI 1.39-164) compared with wild-types.9) However, a recent study examined the prevalence of heterozygotes for SLC22A5 mutations in 324 patients with cardiomyopathy and demonstrated that heterozygosity for PCD is not more frequent in patients with unselected types of cardiomyopathy and is unlikely to be an important cause of cardiomyopathy.27) Finally, heterozygosity for PCD mutations has been associated with cardiac arrhythmias that resolve after carnitine treatment.39) In any case, considering that about 1% of the population is heterozygous for this potentially treatable condition, more studies with careful follow-ups are deserved in the future

Common supplements include omega-3 fatty acids, vitamins D and B6, magnesium, probiotics, melatonin, and antioxidants like curcumin and quercetin

Ehses JA, Pelech SL, Pederson RA, and McIntosh CH

Tian et al