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GLP1R activation might reduce cardiovascular morbidity indirectly through reductions in glycaemia, blood pressure, inflammation, postprandial lipaemia and body weight

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The goal is identifying and treating the underlying condition causing the elevation

SGLT2 inhibitors (i.e., dapagliflozin) have been proven to strongly promote macrophage polarization towards a M2 phenotype, thus alleviating inflammation and atherosclerotic processes (Lee et al., 2020)

Gastrointestinal side effects play a major role in these early discontinuations