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[10] [11] Based on data from retatrutide clinical trials (NEJM, 2023) and experience with similar approved agents, patients may experience: Redness, swelling, or itching at the injection site, which typically resolves within a few hours to days Bruising or mild pain immediately following injection Nodules or localised reactions beneath the skin, which may occur with repeated injections at the same site These reactions are generally mild and self-limiting

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309 (4), E345E356

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Who Should Monitor Menstrual Changes and When to Seek Provider Guidance Women of reproductive age, those with polycystic ovary syndrome (PCOS) history, or those with baseline irregular cycles warrant heightened baseline assessment and monthly tracking

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