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This study further demonstrated that exendin-4 treatment additionally reduced the presence of key inflammatory molecules, including TNF-alpha, interleukin 1 beta (IL-1beta), and IL-6, in mice livers [46], providing evidence for potential GLP-1 treatment for inflammation related to steatohepatitis

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3.1.2 Semaglutide: mechanistic endpoints and effect amplification in combination therapy Evidence for semaglutide tends to focus on mechanistic and tissue-distribution endpoints