The role of R-2-HG as an oncometabolite has been implicated in epigenetic modifications through the inhibition of -KG-dependent dioxygenases and demethylases, which has been assumed to be a driver of tumorigenesis 117,118
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Dysregulation of GABAergic Signalling Contributes in the Pathogenesis of Diarrhea-Predominant Irritable Bowel Syndrome
GLP-1 Access, MariTide Data, and the Oprah Effect on Obesity Care This week on On The Pen , we break down a rare FDA walk-back on GLP-1 safety labeling, major pharma signals coming out of JPM 2026, and the growing tension between patient access and legislative efforts that could restrict compounding
GLP-1 medications are not routinely recommended during breastfeeding due to limited safety data in lactating populations
The transfection efficiency was confirmed by immunoblotting (Figure 3B)