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However, this activity is insufficient to counteract established disease progression and yield clinical benefits

The discovery of RET mutations and insight gained from the correlation of clinical phenotype with specific molecular changes has led to the current classification system (Table 1) (89)

J Hepatol (2014) 61:7307

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Focal accumulation of dark brown pigment was noted, which remained unchanged when stained according to Perls, which allowed us to exclude hemosiderin