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A family history of gallbladder disease can also increase your chances

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Autoimmun Rev 2014

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It has been suggested that PPAR can induce chondrocyte autophagy through the Akt/mTOR pathway, thereby maintaining cell viability and delaying cartilage degeneration 36

They are metabolised via the thiopurine S-methyltransferase (TPMT) enzyme, and polymorphisms in the gene encoding this enzyme can lead to variable enzyme activity and potential toxicity