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However, the limitation of tirzepatide is that it does not directly engage the glucagon receptor , which plays a crucial role in fat metabolism, hepatic energy expenditure, and thermogenesis

Eating excessive fats, fibers and protein can lead to an excessive intake of calories, which will cause weight gain

Two distinct mechanism families overlap here

10.1172/JCI105597 J

Start your intake How GLP-1 Medications Affect Your Body During Acute Illness GLP-1 agonists slow gastric emptying and increase satietymechanisms that reduce appetite but may worsen nausea when combined with viral infection