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Similar content being viewed by others This article describes research in our and other laboratories on mitochondrial metabolism of acetyl-L-carnitine (LAC) that has led to the discovery of novel epigenetic mechanisms for the rapid regulation of brain plasticity in multiple rodent models and then has prompted us to uncover a role for this proposed mitochondrial signaling pathway of epigenetic function as a therapeutic target for clinical phenotypes of depression linked to childhood trauma, and implications for Alzheimers disease (Fig

The Trump administration announced in April 2025 that Medicare would not cover GLP-1 drugs for weight loss, reversing a Biden-era decision

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In cases of deficiency, a few key amino acids can be supplemented