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Once inside hepatocytes, UDCA is conjugated primarily with glycine or taurine and transported into bile ducts via the bile salt export pump (BSEP), promoting bile secretion and preventing the accumulation of toxic bile acids ( Figure 3 The choleretic effect of UDCA is central to its therapeutic action in PBC
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Acknowledgments We thank Dr Maja Aleksic, Dr Matthew Dent, and Dr Carl Westmoreland for providing comments that improved the manuscript
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Compared to Hexarelin (historically the most potent GHRP), Ipamorelin avoids the rapid desensitization and marked cortisol and prolactin increases reported with Hexarelin in prolonged use
