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After discontinuation, meaningful plasma levels may persist for several weeks, which is clinically relevant for surgery, pregnancy planning, or new medication introduction

Thorpe KM, Patel C, Harrison R, Eapen Z, Ambrosy A, Coker R, Jenkins W, Anderson M, Migdalis I, Eliasson B, Chiang C, Cuadrado J, Santos NG, Litvak M, Loureyro J, Maldonado N, Gaal LV, Mihaylova-Shumkova R, Akhras R, Grondin F, Gupta M, Jones M, Lonn E, Lastuvka J, Cadinot D, Chevts J, Grosskopf J, Heymer P, Jung T, Luedemann J, Maxeiner S, Milek K, Regner S, Rieker W, Seufert J, Dimitriadis G, Pagkalos E, Mucsi J, Bonadonna R, Cosmo SE, Ponzani P, Trevisan R, Jang HC, Lee EY, Yu J, Vidrio-Velzquez M, Viergever EP, Guttormsen G, Wium C, Gadzinski W, Krzyzagorska E, Madej A, Romanczuk P, Garganeeva A, Kharakhulakh M, Lesnov V, Vasilevskaya O, Dawood S, Calonge AN, Charneco MQ, Rodrguez IR, Lundman P, Sderberg S, Chen JF, Sansanayudh N, Zlova T, Cookson T, Akhter F, Baum H, Aguiar RBD, Cheung D, Cohen A, Farris N, Forgosh L, Hartman I, Hermany P, Kulback S, Labroo A, Little R, Mehta A, Moran J, Rasouli N, Tan M, Wynne A, Yazdani S, Stewart M, Patel P, Sabol MB, Casson E, Hereghty B, Fernandez-Salazar E, Donaldson J, Jarosz M, Richards J, McLaughlin P, Breneman J, Shitut A, Bhosale A, Naicker P, Dumbre S

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Depression, or major depressive disorder (MDD), is currently ranked third in the global burden of disease by the World Health Organisation and is projected to become the leading cause by 2030 [65]

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