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Bariatric surgery, by contrast, may offer a more substantial and longer-lasting improvement in obesity-related health for some patients, particularly where more significant weight loss is needed
As more non-weight indications emerge, including potential applications for addiction, Alzheimer disease, fatty liver disease, and chronic kidney disease, the relevance of BMI as the primary gatekeeper will diminish
Patients should inform their provider about any personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2), as tirzepatide is contraindicated in these cases
CONCLUSION By addressing the unique requirements of people using GLP-1s for weight loss, device teams can develop solutions that support better adherence and create a positive, engaging user experience
2025;50(1):HS2-HS6