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Moreover, several clinical studies show that glycemia improves when doses are increased but with unacceptable rates of gastrointestinal adverse events 16,17,18 , suggesting that maximum benefits from GLP-1R agonism are in fact not realized with current treatments

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However, glycemic control per se cannot fully prevent or improve DPN, especially in patients with type 2 diabetes mellitus (T2DM) [6-8]

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