There are similar concerns for companies that make much of their money due to the obesity epidemic
Based on current clinical guidelines and our patient experience: Strong indication: BMI 30 (obesity) without active contraindications BMI 27 (overweight) with weight-related comorbidities such as hypertension, dyslipidaemia, type 2 diabetes, sleep apnoea, or fatty liver disease Patients who have attempted weight management through diet and exercise without sustained results Patients who have plateaued with other weight management interventions Relative indication (clinical judgement): BMI 25-27 with specific metabolic drivers (pre-diabetes, insulin resistance, PCOS) Patients preparing for weight-related surgery or other medical interventions Patients with specific body composition goals beyond BMI criteria Not indicated or contraindicated: Pregnancy, breastfeeding, or pregnancy planning within next 2 months Personal or family history of medullary thyroid cancer or MEN2 syndrome Personal history of pancreatitis Active severe gastroparesis or severe gastrointestinal disease BMI below 25 (cosmetic use for body contouring in normal-weight individuals is not appropriate) Eating disorder history GLP-1 use can be problematic for patients with restrictive eating patterns Frequently asked questions Is Ozempic "better" for weight loss than Wegovy
Though research is limited, in vitro and in vivo studies have alluded to the potential of semaglutide exerting anti-inflammatory effects by decreasing glucotoxicity, immune cell recruitment, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and various pro-inflammatory cytokine expression, lipotoxicity, and oxidative stress
Healthcare providers typically consider the overall benefit-risk profile of a medication when prescribing it to patients
There are some of these drugs approved for chronic weight management, such as Wegovy, while others, such as Ozempic , are approved for treating type 2 diabetes but may also be prescribed off-label for weight loss in adults
Customizing Your Protocol Every individuals nutritional needs are unique
