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placebo (17%), sitagliptin (28%), or exenatide ER (28%), and a post-hoc analysis indicated that reductions with semaglutide were primarily mediated by weight loss (143, 152, 165167)

There are mixed opinions on whether intermittent fasting offers unique metabolic or longevity benefits over other structured dieting methods, such as calorie tracking or macro-based eating

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GLP-1 receptor activation in these regions enhances satiety signaling and may contribute to the nausea that some patients experience with GLP-1 medications, particularly during dose escalation

Genetics 179(1):4157