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Serious Side Effects While less common, some serious side effects associated with Ozempic require immediate medical attention: Pancreatitis: Inflammation of the pancreas can be a serious side effect

10.1016/j.jneuroim.2018.09.003 J

Appetite reduction is often the earliest noticeable effect, reported within the first one to two weeks due to GLP-1 activity on hypothalamic satiety signalling

Moreover, some research points to direct effects of receptor agonists on the cardiovascular system, including improved arterial stiffness and reduced sympathetic nervous system activity, both of which can help lower blood pressure

The more recent SELECT trial, published in the New England Journal of Medicine in 2023 and highlighted by the American Heart Association, showed a 20% reduction in major cardiovascular events in patients with overweight or obesity and pre-existing cardiovascular disease but without diabetes

Diabetes Care 49 , 15541559 (2006)