The drug is a once-a-week injection that combines two hormones, GLP-1 and GIP, which work in combination to stimulate insulin secretion and reduce appetite
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References: Aroda, V
[8] [9] [10] [11] Although reduced GLP-1 secretion has previously been associated with attenuated incretin effect in patients with type 2 diabetes, further research indicates that GLP-1 secretion in patients with type 2 diabetes does not differ from healthy subjects
In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]
Even if retatrutide is priced high, cost and insurance coverage will be a factor in patients ability to access it throughout the world