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The present model corroborates previous findings of synapse-like remodeling around DRG somata in chronic pain and synaptic marker enrichment in human DRG neurons revealed through increased PSD95 and synaptophysin levels in the DRG (Sun et al
Reif A, Herterich S, Strobel A, Ehlis AC, Saur D, Jacob CP, et al
For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM, that explain poor responders to their medications. The biological basis of GLP-1 resistance is still unknown and is likely complex
CARMELINA investigators
In contrast, operational genes (genes primarily involved in housekeeping), have been inherited by horizontal transfer
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