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The limited availability of free CoA leads to the arrest of the beta-oxidation process and to the accumulation of harmful long-chain acylCoA and acylcarnitines in the mitochondria

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network adequacy) are considerations in the negotiations between hospitals and payers and network needs involve anticipated patient utilization, we do not believe that hospitals and payers would consider anticipated patient utilization when negotiating contracts without considering the resources necessary (that is, costs) to provide those items and services for that level of patient utilization anticipated

Aliment Pharmacol Ther 41:12371245