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Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP CTF

PLoS ONE, 5 (1), e8976

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114,115,116 Additionally, NADH or FADH 2 is the electron carrier for the mitochondrial membrane proteins, such as GPDM and FQR, and the metabolic enzymes in matrix, such as OGDH and PDH, all of which contribute to ROS production

A deficiency in Vitamin B12 can lead to various health problems, ranging from fatigue to permanent neurological impairments