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This echoes the clinical practice already emerging with semaglutide and tirzepatide, where some prescribers step patients down after target weight is achieved

When the fat layer thins after weight loss, these bands become more visible

Similar patterns have been observed with liraglutide in the SCALE trials and tirzepatide in the SURMOUNT-4 study, suggesting this is a consistent finding across multiple incretin-based anti-obesity agents

Over-suppression of cholesterol

25,26,27 A systematic review revealed that the prevalence of osteoporosis in IBD patients ranged from 2% to 15%, and CD patients may have a higher risk than UC patients

However, since liraglutide administration significantly reduced food intake (Supplementary Fig