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Poor hydration can lead to reduced performance, increased fatigue and a greater risk of injury

In vivo studies confirmed that Ghrelin significantly activated the BMP6/SMAD1 signaling pathway in the brain tissue of AD mice, thereby inhibiting microglial ferroptosis, promoting microglial polarization toward the M2 phenotype, and ameliorating learning and memory deficits in AD mice ( In vitro , Neuritin activated the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway in A 1-42 -stimulated HT22 neuronal cells, leading to increased NADK activity and NADPH expression, reduced MDA and ROS levels, and inhibition of neuronal ferroptosis

Another notable factor Huberman talks about regarding sleep supplementation is dependency

L., Chen, S., Lutz, T

Bril, F

Cell Metab (2016) 23(1):1326