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CorradiniEBuzzettiEDongiovanniPScarliniSCaleffiAPelusiSet al

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The most frequent adverse events reported were injection site reactions, an increase in skin pigmentation, and nausea

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Normal inflammatory reactions peak at 1224 hours and then begin to fade

The authors also demonstrated that the NPY-Y1 receptor antagonist (BIBO-3304) was able to reduce AHR and airway inflammation in wild-type mice, implying a new therapeutic avenue for the treatment of asthma