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In addition to glucose control improvements, GLP-1-RAs, especially dulaglutide and semaglutide (17), stimulate significant weight loss by reducing gastric emptying, stimulating satiety, and decreasing food intake (18) by acting on peripheral and central receptors in the gut and brain (10)

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More research is therefore needed to better understand the safety and benefit GLP-1s offer to children and adolescents and to better understand their place in the broader continuum of weight management.