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In a randomized, double-blind, placebo-controlled pilot trial, Nascimento et al

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Takeaway: Fueling Weight Loss with Awareness Scientific American reports that weight loss includes the loss of both fat and muscle

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Menstrual irregularities An analysis of over 410,000 social media posts (self-reported anecdotal evidence) by people taking semaglutide or tirzepatide found that menstrual irregularities were among the most commonly self-reported side effects not well captured in clinical trial data, suggesting this may be more prevalent than official labelling indicates

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In conclusion, GLP-1 receptor agonists show potential in heart failure management through their multiple mechanisms of action, including direct cardioprotective effects, vasodilation, natriuresis, and glucose and weight control

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