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GLP-1 receptor agonists represent a significant shift in metabolic treatment, but actual out-of-pocket costs vary widely based on insurance, pharmacy choice, and individual medication response

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They are not required to demonstrate efficacy, and they do not need to prove that their delivery method works as claimed before reaching the market

Patients with known diabetic retinopathy treated with semaglutide and insulin should be monitored closely including periodic eye examinations by an ophthalmologist and treated according to clinical guidelines

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