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The complex was subjected to size-exclusion chromatography (SEC) on a Superose 6 Increase 10/300 column (GE Healthcare) equilibrated with 20 mM HEPES pH 7.5, 100 mM NaCl, 2 mM MgCl 2 , 1 M semaglutide, 0.01% (w/v) LMNG, and 0.006% (w/v) CHS

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47 The doses of semaglutide available for subcutaneous injection are 0.25 mg, 0.5 mg, 1 mg, or 2 mg for type 2 diabetes, and 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, or 2.4 mg for obesity, respectively