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Hepatic clearance accounts for roughly 25% of total apixaban elimination, primarily through CYP3A4 with minor contributions from CYP1A2, CYP2C8, CYP2C9, CYP2C19, and CYP2J2 [2]
The presence of blood should never be ignored
I just think that is always in my mind of like, Is this safe for someone to do, and is this going to have any long-term effects? To Lennys point, theres one study in PFJ, like 7 of 12 patients reported subjective improvement in 6 months
Less water means higher concentration
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This suppresses transcription of pro-inflammatory genes, reducing TNF-alpha production and IL-6 secretion
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