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Second, continued supply constraints and insurance barriers for branded GLP-1 medications ensure ongoing demand for affordable compounded alternatives

GLP-1 RAs are a promising treatment option for patients whose disease is characterized by a combination of metabolic and immune dysregulation

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However, patient preference for oral therapies has limited early-line use of GLP-1s

36,37 Findings from other research studies have contradicted this proposition, however, showing that the association between hyperphosphatemia and liver failure is only evident in patients with acute renal failure (with 5080% of patients with acute liver failure having concomitant acute renal failure 38 )