21 In head-to-head trials, gastrointestinal effects appeared to be greater with liraglutide than exenatide extended-release (DURATION-6) 13 and albiglutide (HARMONY-7) 17 , but liraglutide-treated patients experienced less nausea than those receiving exenatide twice daily (LEAD-6)
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Although this difference approached but did not reach the threshold for clinical significance established in other studies, 134 the findings suggest the potential neuroprotective effects of lixisenatide, possibly mediated by increased synaptic dopamine levels, as supported by preclinical and clinical research in addictive disorders
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