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Supplementary information This file contains Supplementary Tables 1-3

Funding 1

One-week washout, then start tirzepatide at a mid-range dose

For compounded semaglutide, consistency and safety rely on choosing a trusted compounding pharmacy and receiving ongoing monitoring from a healthcare provider

Key Takeaway: The .25 mg dose is designed to help your body adjust to the medication safely, setting a foundation for higher doses later in your treatment program

If your health goals require large, clinically meaningful weight loss for severe obesity, prescription medicines, surgical options or multi-disciplinary care may be necessary