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The FDA label notes this finding but immediately qualifies it by stating that due to species-specific differences in lactation physiology, the clinical relevance is unclear

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Lancet 376:595605 Apovian CM, Aronne L, Rubino D et al (2013) A randomized, phase 3 trial of Naltrexone sr/bupropion SR on weight and obesity-related risk factors (COR-II)

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Thus, in the context of moldy environments, IL13 variants do not change how mycotoxins are detoxified, but they change how vigorously the immune system responds in the airways

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More metabolic dysfunction means more room for the drug to work

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