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Statements Author contributions CL: Writing original draft, Writing review and editing

Fuhrmann, A

10.1042/BCJ20160510 14

5.3.8 Inhibition of angiogenesis Dihydroartemisinin inhibited tumor vascularization by decreasing the expression of HIF-1, VEGF, and endothelial cell-specific marker (CD31 and NG2) proteins, leading to a significant reduction in microvessel and mature vessel density in a time-dependent manner (Zhang et al., 2013)

Such trials can cost hundreds of millions of dollars to run

In some of such embodiments, a micronized therapeutic agent comprising micronized particles, coated micronized particles, or a combination thereof, comprises a therapeutic agent as a free base, a salt, a prodrug or any combination thereof