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Treating primary muscle cells, C

All treatment studies were randomized and injections were performed by blinded investigators

Symptoms of deficiency, including fatigue, numbness, cognitive fog, and mood changes, may return over weeks to months

151,152 GDH1 depletion results in imbalanced redox homeostasis and cell cytotoxicity and attenuates cancer cell proliferation, which as well as the results in erythroleukemia cells, while it negligibly affects normal cell proliferation

Higher incidence of cardiovascular events

These observations imply that dynamic coordination between mitochondrial function and lysosomal activity may be important for stress adaptation in ovarian cells, although direct mechanistic evidence in this context is still limited